Oral minoxidil is becoming an increasingly popular treatment option for hair loss patients. This article will discuss a few background points regarding this phenomenon. LOW-DOSE ORAL MINOXIDIL FOR HAIR GROWTH Over the past 3-4 years, the prescription and use of oral minoxidil for hair loss has increased. This trend was likely driven by several peer-reviewed studies published around 2019/2020, including a study done at the Ramon y Cajal University Hospital in Spain, and a paper published in 2020 by Antonella Tosti and Michael Randolph, both appeared in the Journal of American Academy of Dermatology. Both studies presented an overall favorable opinion of the use of oral minoxidil for androgenic alopecia, and the latter concluded that it “was found to be an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations.” Dating back to over 50 years ago, oral minoxidil first showed signs of hypertrichosis in patients who were using the drug as a hypertensive agent, or a treatment to lower blood pressure. Several years later, a topical formulation of minoxidil was developed, and in 1988 the first version of 2% Regaine was launched in the UK as a treatment for pattern hair loss. Presumably, regulatory agencies and the pharmaceutical company who was developing minoxidil for hypertension had concerns about using it as a systemic treatment for hair loss. For over the past 30 years, topical minoxidil has been a staple hair loss treatment and a household name, as one of the only 2 FDA approved treatments for hair loss. Topical use of the product has come with mixed results among patients, mostly due to the varying amounts person-to-person of sulfotransferase, or SULT1A1, enzymes which are found in one’s hair follicles. The SULT1A1 enzyme is needed to convert minoxidil to its active form minoxidil sulfate within the hair follicle in order for the drug to promote a significant hair growth effect. It is a common theory that oral minoxidil outperforms topical minoxidil in hair growth efficacy due to facts that 1) the liver converts minoxidil into its sulfated form via phenol sulfotransferase and negates the need for hair follicle SULT1A1 levels and 2) the treatment naturally goes systemic and is more present in the bloodstream. Low-dose oral minoxidil is established to be at a dose of 5mg or lower. DISCUSSION Interest from multiple readers of this site prompted me to write about the use of low-dose oral minoxidil (OM) for hair growth, otherwise, I figured that most people were already aware of the possibility of getting this drug prescribed to them. Throughout various messaging channels on the internet, it is possible to find a multitude of testimonials from users of oral minoxidil, many positive, and some of them show very impressive results. Alternatively, you can also find remarks from users who experienced adverse effects from the drug and subsequently discontinued its use. A topic for which I have yet to find literature for, and one which I think deserves attention, is suggesting the lowest efficacious dose of OM for AGA, or “microdosing” OM. For a dermatologist’s perspective on the use of low-dose OM for AGA, see a review written for the JAAD which includes clinical trial data and mentions the warnings associated with the drug. Several years from now, it may be possible to evaluate longer term use of low-dose OM for AGA and compare its safety to the relatively short-term studies linked above, which were found to be generally favorable. Low-dose oral minoxidil should always be used under doctor’s supervision. from Follicle Thought
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