Study sheds light on McSCs function and how their decline might be reversed, opening doors to new treatments and deeper insights into aging Stem cells hold the secret to regenerating tissue and maintaining youthful features. Yet, certain cells, such as melanocyte stem cells (McSCs), fail earlier than others, leading to visible signs of aging like gray hair. Recent discoveries published in the journal Nature have shed light on how McSCs function and how their decline might be reversed, opening doors to new treatments and deeper insights into the biology of aging. Understanding Hair Pigmentation and Stem Cell Function McSCs, located within hair follicles, are key to hair pigmentation. These cells move between compartments of the follicle, toggling between stem cell and transit-amplifying states. This mobility allows them to self-renew and generate pigment-producing melanocytes. However, unlike other stem cells, McSCs exhibit a unique ability to reverse their differentiation. Live imaging and single-cell RNA sequencing reveal that McSCs respond to local cues, such as WNT protein signals, which guide their differentiation. These signals are critical during hair follicle regeneration. For instance, during the growth phase of hair follicles, McSCs migrate downward and differentiate into melanocytes that pigment the hair. However, with age, McSCs become stranded in the hair follicle bulge, losing their ability to regenerate and mature. This immobility leads to graying hair. Research at NYU Grossman School of Medicine has shown that aging accelerates McSC depletion. In mice studies, physically aged by plucking and forced regrowth, nearly half of McSCs became trapped in the follicle bulge, up from 15% in younger specimens. These trapped cells failed to regenerate or mature into pigment-producing melanocytes. Conversely, McSCs that maintained their mobility continued to regenerate and produce pigment over a two-year period. This phenomenon highlights the distinct nature of McSCs compared to other stem cells. While hair follicle stem cells move unidirectionally along a maturity timeline, McSCs uniquely oscillate between differentiation states. This plasticity is essential for maintaining hair pigmentation but appears to diminish with age. “It is the loss of chameleon-like function in melanocyte stem cells that may be responsible for graying and loss of hair color,” explains Dr. Mayumi Ito, senior investigator of the study. She adds, “Our findings suggest that motility and reversible differentiation are key to keeping hair healthy and colored.” The Role of WNT Signaling and Future Directions WNT signaling plays a pivotal role in McSC function. In earlier studies, this pathway was shown to stimulate McSCs to mature and produce pigment. However, the follicle bulge exposes McSCs to significantly fewer WNT signals compared to the germ compartment, where these proteins are abundant. This imbalance underscores the importance of cellular mobility for maintaining pigmentation. To further explore these dynamics, the research team plans to investigate methods to restore McSC motility. “If we can physically move jammed cells back to their germ compartment or enhance their motility, we might prevent or reverse graying,” says Dr. Qi Sun, lead investigator of the study. Potential approaches include using small molecules or other agents to encourage McSC movement. These interventions could not only preserve hair color but also provide insights into aging mechanisms in other tissues. McSC plasticity suggests that similar principles might apply to stem cells responsible for tissue maintenance and regeneration throughout the body. Implications Beyond Hair Color The implications of McSC research extend far beyond aesthetics. Stem cells are vital for tissue regeneration and are studied for their potential to treat various diseases. McSC findings could inform broader research into aging and regenerative medicine. For instance, understanding how to restore stem cell functionality could lead to therapies for conditions where cellular repair mechanisms falter, such as neurodegenerative diseases or certain cancers. Despite their promise, stem cell therapies face ethical and safety challenges. Some worry about the use of embryonic stem cells, while others question the long-term safety of experimental treatments. However, advances in induced pluripotent stem cells—which do not rely on embryos—and rigorous clinical trials provide a path forward. The research at NYU Grossman highlights the transformative potential of stem cell science. By uncovering how McSCs lose functionality and exploring ways to restore their mobility, scientists pave the way for innovative treatments. These advancements not only address cosmetic concerns like graying hair but also deepen our understanding of aging and cellular regeneration. As the research progresses, it may unlock solutions for a wide range of age-related conditions. Perception of Gray Hair in Society The perception of gray hair in society has evolved significantly across cultures and historical periods, reflecting changes in attitudes toward aging, wisdom, and beauty. Ancient and Historical Views:
Middle Ages to Early Modern Period:
19th and Early 20th Century:
Mid-20th Century:
Late 20th Century to Present:
Today, gray hair is often celebrated as a symbol of confidence and individuality, signaling a broader acceptance of aging and natural beauty in many parts of the world. However, attitudes remain complex and vary depending on cultural, generational, and social factors. The study's co-authors include Minwoo Kim, Bo Zhang, Vivian Lee, Bin Wu, Zhiwei Ma, Michael Peckerar, Luiza Baptista, Sadegh Davari, David R. Drummond, Jessica G. Yeh, and Elsa Quintana-Bustamante.
Note: Materials provided above by The Brighter Side of News. Content may be edited for style and length. From appointment deposits to price discrepancies and the rise of the influencer hairstylist. It seems everyone is struggling to secure a reliable hair appointment. Scroll down for a link for the article This is a very well written article, chalked full of valuable insight and information. I have a few take-aways from the article: 1) Social Media Influencers are ruining the salon industry and have been for a while now. And not just the salon industry either. 2) Who in the heck goes to a "stylist" that isn't licensed? We call these individuals "kitchen cosmetologist." That's on you if you don't get what you want or your hair melts or breaks off. God forbid you don't have an allergic reaction to haircolor because they don't know how to do a patch test. Any of this could happen with licensed cosmetologist, too, but more likely by someone who hasn't put in the hours of training and eduction to get their license. "Still, it's important to note that there is a risk when booking hair appointments with social media stylists who are not licensed since there are fewer restrictions than what professional salons would require regarding pricing, a cosmetology license, hygiene, and more." 3) No consultation before someone touches your hair is asking for trouble. A consultation should be an analysis of your hair type and texture, let you know if the style you are wanting is suitable for your face shape, hair type, haircare routine & lifestyle, give you a pretty close estimate as to what the service should cost, how long it will take, and if it might take multiple appointments to achieve the look you want. You'll also know whether the stylist is someone you're comfortable with. This is a relationship you're establishing. And these are just are very bare minimums. 4) Celebrity hair (both women and men) has been manipulated for a photo shoot, movie or event. Usually by a team of stylists. If you're not willing to put in the time (blow-drying, styling and regular appointments) you'll blame me because you can't achieve the look. See #3 above. 5) DO NOT BELIEVE MOST OF WHAT YOU SEE OR READ ON TIKTOK. PERIOD. The internet has a lot of misinformation when it comes to safe hair care. This probably should have been the #1 take-away. "The landscape of hair salon culture has changed indefinitely with the rise of social media and hair stylists taking clients at home rather than being contracted with a salon. So be wary of whether a salon or stylist has hidden service fees or scheduling charges. And when it comes to finding a good salon, Stephen says to scope out the location before your appointment “to see if the space is clean.” Other tell-all signs to gauge reputable stylists or salons include checking stylists' licenses, reviewing their online portfolios, and communicating beforehand with your stylists about all appointment fees and surprise add-ons before they put their hands on your head." Click below to read this article In this report, Teen Vogue's contributor Maria Poggi investigates the
controversy around hair salons and the rise of the social media hairstylist, speaking with stylists and content creators to hear from both sides how things have changed for the worse. This is very distressing news from the UK. If it's happening across the pond, you know it's happening here in the US, too.
Owners say it’s almost ‘impossible’ to hire new stylists after 70% decline in people enrolling in apprenticeships “It is a brilliant, brilliant career...But taking someone on is now very difficult; the talent pool is getting smaller and smaller.” The number of trainees enrolling in hairdressing apprenticeships has declined by 70% over the last decade. This, combined with a wave of high street salon closures, means people in the UK could face a longer wait for an appointment in the years to come. One of the issues, according to industry experts, is hairdressing is perceived by young people to be a low-paid profession. The decline in apprenticeships is also due to school-leavers opting for a college course instead, but salon owners complain this is no substitute for the learning on the job. They say it takes an average of 16 weeks to fill a salon vacancy. After the financial strain caused by closing for long periods during the pandemic, the UK hairdressing industry has struggled to rebuild its fortunes. Salons have had to put up their prices, sometimes several times, but have struggled to pass on to customers the magnitude of business cost increases such as energy and wages during the cost of living crisis. More than two dozen Olaplex users have sued the company over allegations that its luxury haircare products are falsely advertised as safe for those with dry and/or damaged hair. The 61-page lawsuit says that although Olaplex touts the products “over and over” in advertisements as “scientifically proven,” free from harsh chemicals and “safe for all hair,” the items are, in fact, “none of these things.” As the suit tells it, Los Angeles-based Olaplex and co-defendant Cosway Co.’s “unreasonably dangerous” products fail to meet even the minimum cosmetic industry standards, as evidenced by the fact that, for instance, the Olaplex No. 3 Hair Perfector once contained lilial, a known sensitizer and allergen linked to infertility. According to the lawsuit, many other purportedly safe Olaplex products contain panthenol and other ingredients well known in the beauty industry to be allergens and irritants that can cause allergic contact dermatitis, hair loss and scalp injuries. The case, which was not filed as a class action (more on this below), accuses Olaplex and Cosway of attempting to conceal the dangers of their products, leading many users to believe that their hair loss and scalp issues “could be symptoms of a dire health condition.” Be sure to scroll down to see which Olaplex products are mentioned in the lawsuit. In addition, Olaplex’s marketing – which includes the use of celebrity photos – is misleading given that “many of these celebrities do not regularly use the Products,” much less sponsor or endorse them in any way, the filing claims. Further, much of the defendants’ press coverage amounts to “no more than a purchased ad” or paid mentions in blogs and by influencers on social media, the suit, filed on February 9 in California, relays. Further still, many of the before-and-after photos on Olaplex’s website that show how “the average person can attain celebrity hair” feature paid models who “do not regularly use the Products” as recommended by the defendants and whose hair, unbeknownst to consumers, has been styled by professionals, the case claims. Despite “thousands” of complaints, Olaplex conceals dangers of haircare products, suit claims According to the case, Olaplex has affirmatively tried to hide the dangers of the products from the public, prohibiting many users from discovering that their injuries were caused by the company’s “wrongful conduct.” “It never occurred to Plaintiffs and other users that the Products—touted by Defendants as safe for all hair, free of a laundry list of harsh chemicals and are [sic] scientifically formulated and proven to repair dry and damaged hair—could actually be hurting their hair and scalp, not helping,” the lawsuit summarizes. “To the contrary, many believed their situation would have been worse but for the Products.” The case claims Olaplex has made matters worse by failing to disclose and, in fact, actively concealing the sheer number of complaints it has received of hair loss, scalp issues and other injuries from customers and the FDA. Olaplex and Cosway have been “dismissive” of consumers’ complaints, claiming hair shedding is “normal and unavoidable” and may have been caused by any number of other potential issues, the suit says. Had the companies been transparent as far as the volume of complaints they received, consumers could have identified the source of their hair loss and scalp issues much sooner – and some could have avoided injury altogether, the lawsuit contends. Despite the foregoing, Olaplex products remain on store shelves, the complaint shares. Olaplex and Cosway have instead implemented “what is essentially a voluntary and entirely self-serving partial recall,” merely allowing customers to return Olaplex products with “no questions asked” for a full refund, regardless of the date of original purchase or amount of product left in the bottle, the case relays. “Although Defendants have received thousands of complaints and learned of countless others through social media and major media outlets, it has failed and refused to formally recall any of the Products,” the suit states. “Nor have Defendants issued any new warnings or otherwise disclosed the defects and dangers associated with the Products.” As the case tells it, the defendants’ seemingly half-hearted recall amounts to an attempt to “appease injured consumers and sweep under the rug the dangers presented by the Products.” Olaplex ingredients include allergens, could allow for benzene exposure Per the case, many of the Olaplex products at issue contain sodium benzoate and ascorbic and/or citric acid – chemicals that, when combined, create the known carcinogen benzene. The filing stresses that benzene is “so dangerous that the beauty industry has stopped using the ingredient” and voluntarily pulled hair care products containing the substance from stores. The suit adds that the Olaplex products also contain non-water-soluble substances that can cause users to develop “clogged, inflamed, impacted and infected hair follicles.” This condition, known as seborrheic dermatitis, is characterized by “red, itchy, inflamed, blistered, flaking or scaling skin” and hair loss, the suit says. According to the lawsuit, each variety of Olaplex products contains “known skin irritants and sensitizers,” which can cause allergic contact dermatitis and, consequently, “extreme diffuse hair loss.” In more serious cases, exposure to the allergens in Olaplex items can trigger an auto-immune response, such as alopecia areata, the suit adds. The case also contends that Olaplex products include an excessive amount of “plasticizing agents” such as glycol, the overuse of which can weaken and damage hair. With regard to the Olaplex products’ one-time inclusion of lilial, a synthetic scent ingredient, the lawsuit says the European Union Scientific Committee on Consumer Safety in 2020 demanded that the ingredient be phased out of hair and beauty products by March 2022. According to EWG.org, lilial has been identified as having endocrine-disrupting properties, meaning it can interfere with natural hormone functions and may pose a risk to fertility and fetal development. A review of an archived version of Sephora’s website shows that the beauty retailer required Olaplex to remove lilial from its products in 2020 or early 2021, the case says. According to its own public statements, however, Olaplex did not remove lilial from products sold elsewhere in the U.S. and European Union until February 2022 and, at any rate, should have pulled the items entirely from stores, the lawsuit says. Olaplex should have recalled the dangerous Products, requiring that retailers and distributors either (1) return these Products, or (2) destroy them and provide proof of destruction. Instead, we understand Olaplex continues to sell and allows retailers and distributors to continue to sell the runoff inventory it knows contains a dangerous ingredient.” Lastly, the complaint contends that the instructions for using Olaplex products exacerbate the injuries experienced by consumers, who are directed or encouraged to leave the products in their hair for “long periods of time or indefinitely.” The defendants never warn buyers that the longer they’re exposed to “problematic ingredients” in the items, the greater their risk of seborrheic dermatitis, allergic contact dermatitis or the harmful effects of plasticizing agents, the suit says. Which Olaplex products are mentioned in the lawsuit? The Olaplex products mentioned in the lawsuit include Olaplex No. 0, Olaplex No. 1, Olaplex No. 2, Olaplex No. 3, Olaplex No. 4, Olaplex No. 5, Olaplex No. 6, Olaplex No. 7, Olaplex No. 8 and Olaplex No. 9. According to the case, each plaintiff has experienced “serious injury” as a result of using Olaplex products. Some have lost hair—“in some cases more than half and leaving bald spots in others,” the suit says—while others have been left with hair that’s “dry, brittle, frizzy and dull.” “The hair has split and broken, causing it to look unkept and as if it were cut with a weedwhacker,” the case describes, noting that the products have also changed the texture of the plaintiffs’ hair while causing scalp injuries such as “extreme itchiness, rash, yeast infection, bacterial infection, open sores, burning and overall sensitivity,” as well as psychological harm. Is this lawsuit a class action? No, the lawsuit detailed on this page is not a class action, a type of lawsuit filed by one or more individuals on behalf of a larger group who allegedly suffered a similar – but relatively small – injury, usually financial in nature. The 28 plaintiffs who filed the case are instead pursuing damages for their “personal injuries, primarily to their hair and scalp” and want the court to order Olaplex to stop its “unfair, false and deceptive advertising and marketing.” This doesn’t rule out, however, the possibility of a class action being filed over Olaplex products in the future to compensate those who purchased the products and may have been misled by the defendants’ claims. If you want more information on how to start a class action lawsuit, head on over to this page. Spate’s 2022 Trends Report includes data on U.S. consumer search trends in professional services, lipstick, and seasonal products.
A commonality across the entire makeup category is the increased search volume for mature skin. Spate suggests brands take note and develop products suitable for all consumer groups. Hair Dusting & Beauty Services There are 2.7K average monthly searches in the United States for hair dusting—a hair trimming technique that involves cutting off damaged split ends to maintain healthy hair strands and promote growth. The trend has low search volume compared to other hair services but is trending in the right direction, growing 27.5% since last year. Spate reports that hair services are experiencing the highest search growth in the hair category, with a 12% increase since last year. This growth is consistent in other segments, with makeup services increasing 18.6%, skin care services growing by 4.2% and nail services increasing 33.2% since last year. Hair Loss There are 4.5K average monthly searches for hair loss conditioners, a low search volume compared to other conditioner products but also a 54% growth since last year with no market leader. Postpartum hair loss search rates are experiencing the highest growth among hair concerns, with a 14.8% increase since last year. Hair care products like scalp serum and hair loss cream have increased 34.5% and 21%, respectively. Thigh Cream There are 1.6K average monthly searches for thigh cream, a low volume relative to other leg care searches, but also a 59.3% growth since last year. There is medium market competition and Clarins is currently the market leader. Related searches include cellulite, chafing, how to use, what is and review. Spate’s report indicates that thigh cream is a top growing bath and body trend during warmer seasons. Spate suggests that brands consider adding SPF benefits to their thigh creams. There are 27.5K average monthly searches for cream blush, a high search volume compared to other blush products and the largest increase in the blush category. The trend has grown 20% since last year and currently has high market competition with six market leaders: Maybelline, Milk Makeup, Charlotte Tilbury, Elf Cosmetics, Stila and Beautycounter. Plum Lipstick There are 4.8K average monthly searches for plum lipstick, a growth of 549% since last year, but still a low volume compared to other lipstick product searches. Brands being searched alongside the trend are Clinique, Mac, Bobbi Brown and Nyx. Spate suggests that plum is the new red in lipstick as consumers look for a bold and moody vibe to fit the cold winter. The color has universal appeal, as evident in its related searches for skin, dark skin, pale skin and olive skin. Lipstick had a resurgence in 2021 that continues to show growth, with lipstick palette and metallic lipstick searches increasing 196.6% and 230%, respectively. Lip plumping gloss (132.7% increase) and lip pencils (79%) are other trending lip products. Gua Sha Stone There are 99.1K average monthly searches for gua sha stone, an increase of 47.7% since last year and a high search volume compared to other accessories and devices in the face product category. There is low competition with two brand leaders—Lanshin and Sephora. The gua sha stone is a tool for massaging face or body to improve circulation and skin health. The technique is derived from traditional Chinese medicine. The most common related search term was “how to use” (301% increase), presenting an opportunity for brands to provide education and tutorials on the skin care tool. Jade is the traditional stone used for the tool, but rose quartz is a popular alternative. Crystal products are currently the largest increase in natural beauty-related ingredients, with a 63.5% increase since last year, per the report. |
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