Breakthrough Hair Loss Treatment May Have Been Discovered Using MicroRNA
Male pattern baldness, a type of hereditary hair loss, is very common among men. In fact, about two-thirds of men will experience an appreciable amount of hair loss by the time they reach age 35. And, by the age of 50, this figure rises to 85%. Additionally, a quarter of men will begin to have hair loss even before they are 21. Hair loss can be troubling for menTrusted Source with many reporting that their baldness makes them feel less attractive, depressed, or fearful of growing older. Now, however, researchers say they may have found a promising new treatment for this often emotionally distressing condition. According to the study authors, hair follicles become stiffer due to aging. However, their study, which appears in the journal PNAS, found that softening hair follicle cells by increasing the production of a particular type of microRNA could aid in increasing hair growth and regeneration. Tiny RNA particles may be the key to reversing baldness According to board-certified cosmetic dermatologist Dr. Michele Green, who was not involved in the study, hair follicles have various stem cells that are responsible for the regulation of hair growth. “This new study may have found a breakthrough in hair regeneration using small RNA particles or microRNA,” she explained. “More specifically,” she noted, “miR-205 has been identified as an important microRNA that can potentially stimulate hair growth.” Green said that RNA (ribonucleic acid) is present in all living cells. It acts as a messenger to carry instructions from our DNA to regulate protein production. Hair follicles can become stiffer as we age, which, in turn, affects hair growth. “In this study, researchers found that increasing the production of miR-205 softened the stem cells,” said Green. “By softening the hair follicle stem cells, hair growth increased in both young and old mice.” The effect was fairly quick, as well. Green noted that there was increased hair growth after just ten days. How this would be different from current baldness treatments Dr. Ken L. Williams, Jr., a hair surgeon and founder of Orange County Hair Restoration in Irvine, CA, who was also not a part of the study, explained that current FDA-approved treatments for hair loss and thinning in both men and women include:
“Hair restoration surgery is also a successful surgical decision for patients who meet criteria,” he added. Green further explained that any treatment based on the current study would work via a different mechanism than what we currently have available. “Minoxidil works by shortening the resting phase of the hair growth cycle and elongating the growth phase,” she said. “Minoxidil also reverses follicle miniaturization and stimulates circulation around the hair follicles.” In the case of finasteride, it works by inhibiting DHT, which is a male hormone that is responsible for male pattern baldness. “Hair follicles are sensitive to hormonal changes and especially DHT,” she added. Laser light therapyTrusted Source utilizes light in wavelengths ranging from red to infrared to stimulate tissue regeneration and repair. Finally, she said, PRP involves injecting a concentration of platelets rich in growth factors, which improves the health of follicles, increases blood supply, and stimulates reparative cells. What this could mean for the future of hair loss treatment Williams said, “The final outcomes or medical translation of these types of data is always promising, but is impossible to determine so early after discovery.” However, he noted that it is possible that a new treatment will be developed based on these findings. Green additionally cautioned that the study was only performed on genetically engineered mice. More research is needed before we will know if this process will work in humans, she advised. However, if a new treatment does come to fruition, it will “significantly advance hair restoration,” Green concluded, noting that she believes that researchers will probably look at a topical treatment that delivers microRNA directly into the skin. Williams said, however, that it is too early to know what type of delivery system will be created for miR-205, whether that would be a transdermal injection or an oral tablet. from Healthline
Summary: In a new study, researchers discovered that age-related stiffness in hair follicle stem cells can inhibit hair growth. By enhancing the production of a tiny RNA, miR-205, they managed to soften these cells, encouraging hair growth in both young and old mice. These findings indicate the potential for stimulating hair growth by manipulating cell mechanics. This could pave the way for novel treatments for hair loss, with future tests set to determine whether topically delivered miR-205 can stimulate hair growth in humans. Key Facts:
Source: Northwestern University Coaxing hair growth in aging hair follicle stem cells Softening stiff hair follicle stem cells with a microRNA regrows hair  Just as people’s joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study. But if the hair follicle’s stem cells are softened, they are more likely to produce hair, the scientists found. Northwestern scientists discovered how to soften up those stem cells to enable them to grow hair again. In a study in mice published this week in PNAS, the investigators report that they can soften the stem cells by boosting the production of a tiny RNA, miR-205, that relaxes the hardness of the cells. When scientists genetically manipulated the stem cells to produce more miR-205, it promoted hair growth in young and old mice. “They started to grow hair in 10 days,” said corresponding author Rui Yi, the Paul E. Steiner Research Professor of Pathology and professor of dermatology at Northwestern University Feinberg School of Medicine. “These are not new stem cells being generated. We are stimulating the existing stem cells to grow hair. A lot of times we still have stem cells, but they may not be able to generate the hair. “Our study demonstrates the possibility of stimulating hair growth by regulating cell mechanics. Because of the potential to deliver microRNA by nanoparticles directly into the skin, next we will test whether topically delivered miR-205 can stimulate hair growth first in mice. If successful, we will design experiments to test whether this microRNA can promote hair growth potentially in humans.” This study was conducted in genetically engineered mouse models. The scientists used advanced microscopy tools, including atomic force microscopy, to measure the stiffness and two-photon microscopy to monitor cell behaviors in live animals. The article is titled “MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells.” Other Northwestern authors include Jingjing Wang, Yuheng Fu and Kathleen Green. Funding: This study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases grants AR066703, AR071435, AR043380, AR041836 and P30AR075049 of the National Institutes of Health. About this genetics research news
Author: Marla Paul Source: Northwestern University Contact: Marla Paul – Northwestern University Image: The image is credited to Neuroscience News Original Research: Open access. “MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells” by Rui Yi et al. PNAS Abstract MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells Stiffness and actomyosin contractility are intrinsic mechanical properties of animal cells required for the shaping of tissues. However, whether tissue stem cells (SCs) and progenitors located within SC niche have different mechanical properties that modulate their size and function remains unclear. Here, we show that hair follicle SCs in the bulge are stiff with high actomyosin contractility and resistant to size change, whereas hair germ (HG) progenitors are soft and periodically enlarge and contract during quiescence. During activation of hair follicle growth, HGs reduce contraction and more frequently enlarge, a process that is associated with weakening of the actomyosin network, nuclear YAP accumulation, and cell cycle reentry. Induction of miR-205, a novel regulator of the actomyosin cytoskeleton, reduces actomyosin contractility and activates hair regeneration in young and old mice. This study reveals the control of tissue SC size and activities by spatiotemporally compartmentalized mechanical properties and demonstrates the possibility to stimulate tissue regeneration by fine-tuning cell mechanics. 5/25/2023 Why is Rosemary Hair Oil Trending? Analysis of Google search data has revealed that online searches for ‘rosemary oil’ have skyrocketed 135% over the past year in the UK due to the huge surge of interest generated through TikTok. A new finding by beauty and wellness marketplace Fresha analyzed Google search data for searches related to the hair hack, which revealed a 135% increase over the past year and a 695% increase over the past five years just in the United Kingdom. Searches for ‘rosemary oil’ have also gained interest across the globe, with an increase in worldwide searches of 331% over the past five years. The interest in rosemary oil gained popularity on social media app TikTok after beauty and wellness influencers shared their experiences using the product while showcasing the results after around six weeks. “The power of social media, especially TikTok, allows influencers worldwide to share their experiences and knowledge with those who might want to know more about a particular beauty topic but don’t know quite where to start," shares William Zeqiri, founder and CEO of Fresha. "These findings are a definite eye-opener to see just how much exposure TikTok can offer to such a simple and accessible substance like rosemary oil and proves just how many people are interested in natural remedies of haircare which are fun and easily manageable, even if you are a regular salon visitor.” The interest in rosemary oil alongside the hashtag #hairtok has racked up an astonishing number of views. The hashtag #rosemaryoil has totaled 1.3 billion views, alongside #rosemaryoilforhairgrowth reaching 212.3 million views, proving the curiosity of TikTok users in the oil. What does rosemary oil do to your hair? The oil stimulates and promotes hair growth, battles against dandruff and prevents premature graying. It is also proven to add shine and a healthy glow to the hair after a more extended period of regular use. The beauty influencers on TikTok recommend using rosemary oil as part of your hair care routine, not to expect results after the first few uses and sticking with it as you could see incredible differences in your hair's health even after six weeks. How often should you use rosemary oil in your hair? It is recommended if you have thinner, lighter and easily damaged hair, you should use the oil once a week as a treatment. If dandruff is what you want to battle, then use a few drops of rosemary oil alongside gentler oils such as coconut, caster or jojoba oil. It can be used up to four times a week for shorter periods of time. Mixing rosemary oil with lighter oils such as these will help dilute the rosemary oil's strength and work to soothe and nurture the hair while using the natural oils. from BeautyLaunchPad
Niacinamide, a type of Vitamin B3 is found in foods like meat, milk, fish, eggs, veggies and cereals. Here's its benefits for hair health explained by a dermatologist.  Niacinamide is a water-soluble vitamin that can assist in healthy hair growth. (Freepik) If you are suffering from hair fall, thinning of hair and a lot of hair damage, and tried almost all the hair growth products available on the shelves, it's time to go back to basics and fix your diet. Niacinamide, a type of Vitamin B3, can do wonders for your hair health by preventing inflammation in the scalp, enhancing blood circulation and aiding in production of keratin, an important protein for our hair health. Niacinamide should not to be confused with niacin which is another type of Vitamin B3. However, if you have excess niacin in your body, it gets converted into niacinamide by your body. Niacinamide is found in foods like meat, milk, fish, eggs, green veggies and cereals. It is also found in various hair care products. One can either consume foods rich in this important vitamin or apply it externally. "Vitamins play an important role in maintaining our hair health. Niacinamide aka Vitamin B3 is one such ingredient for hair health. Also known as nicotinamide, this vitamin is water soluble and aids in many functions of body such as reducing oxidative stress, metabolizing proteins, and lipids, improve cellular energy and synthesize the carbohydrate to be used by the body. It is also useful in regulating sebum production in the body," says Dr. Rinky Kapoor, Consultant Dermatologist, Cosmetic Dermatologist & Dermato-Surgeon, The Esthetic Clinics Mumbai, India. "Niacinamide is a water-soluble vitamin that can assist in healthy hair growth. Its antioxidant properties can improve blood circulation, and bring oxygen to the hair follicles, resulting in good hair growth. It helps keep the hair lustrous by maintaining sheen and strength. It supports a healthy scalp by balancing moisture and creating a protective layer that enables healthy hair growth. It reduces scalp inflammation and promotes thicker hair growth and improved alopecia," says Dr Anup Dhir, senior consultant, Apollo Hospital and ex-president, Indian Association of Aesthetic Plastic Surgeons. BENEFITS OF NIACINAMIDE Dr Rinky Kapoor shares amazing benefits of using niacinamide for hair. • It enhances blood circulation: Since Vitamin B3 is in charge of delivering energy, it promotes healthy blood circulation and delivery to oxygen and nutrient to the hair follicles. This improves healthy hair growth and gives the hair sheen and suppleness by improving hair textures. This vitamin also helps in bring health back to chemically damaged hair.
• Helps in Keratin synthesis and production: Keratin is a natural protein that is essential for hair as our hair is 90% keratin. Niacinamide increases protein production leading to high levels of keratin which in turn gives bouncy and healthy hair with less breakage and brittleness. • Calms down scalp inflammation: Inflammation is one of the primary causes of hair fall in men and women. Niacinamide can reduce the redness and inflammation in the scalp and prevent hair fall from worsening. The hair become thicker and fuller. • Promotes thicker hair growth: Since the follicular healthy improves with nicotinamide because of reduced oxidate stress, the hair does not go into the resting phase of the growth cycle early on. This improves the texture and thickness of the hair, and the overall look becomes voluminous. • Protects hair from environmental damage: Niacinamide has excellent antioxidant properties that protect the hair from harmful effects of UV rays and also prevent the pollution, heat etc. from drying the hair. This fortifies the lipid barrier and if you are fond of using heating and styling tools, niacinamide can help protect it from the damage. I've been reading about the benefits of Rosemary oil for a while now. It's anti-inflammatory properties make it ideal for general hair health and scalp healing. It's also said that it is as good if not a better option than Minoxidil. Only time (and regular use) will tell, right. This article references a couple Rosemary oil based products you might want to try. One of them (Mielle Organics Rosemary Mint Scalp & Hair Strengthening Oil) got a lot of media attention recently when production couldn't keep up with the new demand. The other one (Weleda's Revitalizing Hair Tonic) is from Switzerland and the one I'm currently using.  What Oil Is The Best For Hair Growth & Thickness? We Explain The great news is that there are a huge number of products out there that can help promote hair growth and thickness. Are you looking for a brand new way to get the gorgeous, thick, and healthy hair of your dreams? The great news is that there are a huge number of products out there that can help promote hair growth and thickness. One of them is oil! In this blog post, we'll explain which oils are the best for promoting hair growth and getting those luscious locks you've always wanted. We will discuss why these oils work so well, how to use them, what their benefits are, and more.
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