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Celebrity hairstylist Jay Small shares the simple ways men can bulk up thin strands and hide hair loss  If you're losing your hair, going in for a haircut might feel like the last thing you want to do. But a smart, stylish cut can make thinning hair appear fuller, according to celebrity hairstylist Jay Small. Small has two decades of experience that includes work with celebrities like Matt Damon, Luke Grimes, and Noah Centineo. He also cofounded Arey, a dietary supplement and hair serum brand for aging and graying hair. The stylist told Insider that "hair thinning and hair loss for men, specifically," is the most common issue he encounters at the salon. Here are his top tips for making thinning, aging hair appear fuller and healthier. A comb-over can look chic if done properly Don't dismiss the comb-over, Small said, especially one done at the hands of a skilled stylist. "I know it's a cliché to talk about a comb-over," he said, but "there are ways in which you can leave a little bit of hair and not have it be very obvious." He recommends a comb-over to some clients who are losing a significant amount of hair on the crown of their head. But maintaining a chic comb-over requires more frequent visits to the salon, to make sure the combing isn't too obvious. A man with thinning hair who chooses to rock a comb-over might need to visit their stylist every four to six weeks to ensure the remaining hair remains neat and not overgrown. Small also recommends using a powdered dry shampoo to minimize greasiness, which can make hair lie flat on the scalp. Keeping hair dry can add volume, making your hair look fuller. He says look for a dry shampoo that is not aerosolized — those spray cans can be loaded with up to 95% propellants like benzene, which isn't actually helping absorb any oil; it's just pushing the spray out of the can. Also avoid dry shampoos with alcohol in them, which can dry out your scalp. Instead, find a small bottle of dry shampoo powder, ideally one where 100% of the ingredients target oil absorption. Consider changing your part or chopping off some length to help your hair look fuller  If you're noticing a visible bald spot on your head, you might want to change up your part so more hair covers the exposed thinning area, Small said. Though the change might feel "awkward" at first, the stylist recommends trying out a new part with wet hair and blow-drying your hair in the direction of the part. Changing your part later on, once hair is dry, might make the hair "stick up" unnaturally, Small said. If you happen to have a longer hairstyle, chopping off some of that length can also help make hair look fuller. "The longer your hair is, the finer your hair will look," he said. Finally, don't let your hair loss deter you from keeping your scalp healthy and clean. If you wash your hair frequently, find a gentle shampoo that won't over-cleanse. You may also want to consider a weekly scrub, like an acid-based exfoliating treatment that can help "balance the bacteria" on your scalp, Small said. Above all, be open with your hair stylist Small says he understands it can be hard for clients to bring up new hair loss issues with their stylist. "A lot of times people aren't really willing to talk about it," he said. He tries to find "tasteful" ways to broach issues or changes he's seeing on a particular client's scalp. "Our job is to have a conversation that a wife or a friend might not have," he said. from Business Insider
Breakthrough Hair Loss Treatment May Have Been Discovered Using MicroRNA
Male pattern baldness, a type of hereditary hair loss, is very common among men. In fact, about two-thirds of men will experience an appreciable amount of hair loss by the time they reach age 35. And, by the age of 50, this figure rises to 85%. Additionally, a quarter of men will begin to have hair loss even before they are 21. Hair loss can be troubling for menTrusted Source with many reporting that their baldness makes them feel less attractive, depressed, or fearful of growing older. Now, however, researchers say they may have found a promising new treatment for this often emotionally distressing condition. According to the study authors, hair follicles become stiffer due to aging. However, their study, which appears in the journal PNAS, found that softening hair follicle cells by increasing the production of a particular type of microRNA could aid in increasing hair growth and regeneration. Tiny RNA particles may be the key to reversing baldness According to board-certified cosmetic dermatologist Dr. Michele Green, who was not involved in the study, hair follicles have various stem cells that are responsible for the regulation of hair growth. “This new study may have found a breakthrough in hair regeneration using small RNA particles or microRNA,” she explained. “More specifically,” she noted, “miR-205 has been identified as an important microRNA that can potentially stimulate hair growth.” Green said that RNA (ribonucleic acid) is present in all living cells. It acts as a messenger to carry instructions from our DNA to regulate protein production. Hair follicles can become stiffer as we age, which, in turn, affects hair growth. “In this study, researchers found that increasing the production of miR-205 softened the stem cells,” said Green. “By softening the hair follicle stem cells, hair growth increased in both young and old mice.” The effect was fairly quick, as well. Green noted that there was increased hair growth after just ten days. How this would be different from current baldness treatments Dr. Ken L. Williams, Jr., a hair surgeon and founder of Orange County Hair Restoration in Irvine, CA, who was also not a part of the study, explained that current FDA-approved treatments for hair loss and thinning in both men and women include:
“Hair restoration surgery is also a successful surgical decision for patients who meet criteria,” he added. Green further explained that any treatment based on the current study would work via a different mechanism than what we currently have available. “Minoxidil works by shortening the resting phase of the hair growth cycle and elongating the growth phase,” she said. “Minoxidil also reverses follicle miniaturization and stimulates circulation around the hair follicles.” In the case of finasteride, it works by inhibiting DHT, which is a male hormone that is responsible for male pattern baldness. “Hair follicles are sensitive to hormonal changes and especially DHT,” she added. Laser light therapyTrusted Source utilizes light in wavelengths ranging from red to infrared to stimulate tissue regeneration and repair. Finally, she said, PRP involves injecting a concentration of platelets rich in growth factors, which improves the health of follicles, increases blood supply, and stimulates reparative cells. What this could mean for the future of hair loss treatment Williams said, “The final outcomes or medical translation of these types of data is always promising, but is impossible to determine so early after discovery.” However, he noted that it is possible that a new treatment will be developed based on these findings. Green additionally cautioned that the study was only performed on genetically engineered mice. More research is needed before we will know if this process will work in humans, she advised. However, if a new treatment does come to fruition, it will “significantly advance hair restoration,” Green concluded, noting that she believes that researchers will probably look at a topical treatment that delivers microRNA directly into the skin. Williams said, however, that it is too early to know what type of delivery system will be created for miR-205, whether that would be a transdermal injection or an oral tablet. from Healthline
Summary: In a new study, researchers discovered that age-related stiffness in hair follicle stem cells can inhibit hair growth. By enhancing the production of a tiny RNA, miR-205, they managed to soften these cells, encouraging hair growth in both young and old mice. These findings indicate the potential for stimulating hair growth by manipulating cell mechanics. This could pave the way for novel treatments for hair loss, with future tests set to determine whether topically delivered miR-205 can stimulate hair growth in humans. Key Facts:
Source: Northwestern University Coaxing hair growth in aging hair follicle stem cells Softening stiff hair follicle stem cells with a microRNA regrows hair  Just as people’s joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study. But if the hair follicle’s stem cells are softened, they are more likely to produce hair, the scientists found. Northwestern scientists discovered how to soften up those stem cells to enable them to grow hair again. In a study in mice published this week in PNAS, the investigators report that they can soften the stem cells by boosting the production of a tiny RNA, miR-205, that relaxes the hardness of the cells. When scientists genetically manipulated the stem cells to produce more miR-205, it promoted hair growth in young and old mice. “They started to grow hair in 10 days,” said corresponding author Rui Yi, the Paul E. Steiner Research Professor of Pathology and professor of dermatology at Northwestern University Feinberg School of Medicine. “These are not new stem cells being generated. We are stimulating the existing stem cells to grow hair. A lot of times we still have stem cells, but they may not be able to generate the hair. “Our study demonstrates the possibility of stimulating hair growth by regulating cell mechanics. Because of the potential to deliver microRNA by nanoparticles directly into the skin, next we will test whether topically delivered miR-205 can stimulate hair growth first in mice. If successful, we will design experiments to test whether this microRNA can promote hair growth potentially in humans.” This study was conducted in genetically engineered mouse models. The scientists used advanced microscopy tools, including atomic force microscopy, to measure the stiffness and two-photon microscopy to monitor cell behaviors in live animals. The article is titled “MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells.” Other Northwestern authors include Jingjing Wang, Yuheng Fu and Kathleen Green. Funding: This study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases grants AR066703, AR071435, AR043380, AR041836 and P30AR075049 of the National Institutes of Health. About this genetics research news
Author: Marla Paul Source: Northwestern University Contact: Marla Paul – Northwestern University Image: The image is credited to Neuroscience News Original Research: Open access. “MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells” by Rui Yi et al. PNAS Abstract MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells Stiffness and actomyosin contractility are intrinsic mechanical properties of animal cells required for the shaping of tissues. However, whether tissue stem cells (SCs) and progenitors located within SC niche have different mechanical properties that modulate their size and function remains unclear. Here, we show that hair follicle SCs in the bulge are stiff with high actomyosin contractility and resistant to size change, whereas hair germ (HG) progenitors are soft and periodically enlarge and contract during quiescence. During activation of hair follicle growth, HGs reduce contraction and more frequently enlarge, a process that is associated with weakening of the actomyosin network, nuclear YAP accumulation, and cell cycle reentry. Induction of miR-205, a novel regulator of the actomyosin cytoskeleton, reduces actomyosin contractility and activates hair regeneration in young and old mice. This study reveals the control of tissue SC size and activities by spatiotemporally compartmentalized mechanical properties and demonstrates the possibility to stimulate tissue regeneration by fine-tuning cell mechanics. Oral minoxidil is becoming an increasingly popular treatment option for hair loss patients. This article will discuss a few background points regarding this phenomenon. LOW-DOSE ORAL MINOXIDIL FOR HAIR GROWTH Over the past 3-4 years, the prescription and use of oral minoxidil for hair loss has increased. This trend was likely driven by several peer-reviewed studies published around 2019/2020, including a study done at the Ramon y Cajal University Hospital in Spain, and a paper published in 2020 by Antonella Tosti and Michael Randolph, both appeared in the Journal of American Academy of Dermatology. Both studies presented an overall favorable opinion of the use of oral minoxidil for androgenic alopecia, and the latter concluded that it “was found to be an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations.”  JAAD 2019; 81: 648-9 Dating back to over 50 years ago, oral minoxidil first showed signs of hypertrichosis in patients who were using the drug as a hypertensive agent, or a treatment to lower blood pressure. Several years later, a topical formulation of minoxidil was developed, and in 1988 the first version of 2% Regaine was launched in the UK as a treatment for pattern hair loss. Presumably, regulatory agencies and the pharmaceutical company who was developing minoxidil for hypertension had concerns about using it as a systemic treatment for hair loss. For over the past 30 years, topical minoxidil has been a staple hair loss treatment and a household name, as one of the only 2 FDA approved treatments for hair loss. Topical use of the product has come with mixed results among patients, mostly due to the varying amounts person-to-person of sulfotransferase, or SULT1A1, enzymes which are found in one’s hair follicles. The SULT1A1 enzyme is needed to convert minoxidil to its active form minoxidil sulfate within the hair follicle in order for the drug to promote a significant hair growth effect. It is a common theory that oral minoxidil outperforms topical minoxidil in hair growth efficacy due to facts that 1) the liver converts minoxidil into its sulfated form via phenol sulfotransferase and negates the need for hair follicle SULT1A1 levels and 2) the treatment naturally goes systemic and is more present in the bloodstream. Low-dose oral minoxidil is established to be at a dose of 5mg or lower.  33 Year Old Female Result Oral Minoxidil (www.irycis.org) DISCUSSION Interest from multiple readers of this site prompted me to write about the use of low-dose oral minoxidil (OM) for hair growth, otherwise, I figured that most people were already aware of the possibility of getting this drug prescribed to them. Throughout various messaging channels on the internet, it is possible to find a multitude of testimonials from users of oral minoxidil, many positive, and some of them show very impressive results. Alternatively, you can also find remarks from users who experienced adverse effects from the drug and subsequently discontinued its use. A topic for which I have yet to find literature for, and one which I think deserves attention, is suggesting the lowest efficacious dose of OM for AGA, or “microdosing” OM. For a dermatologist’s perspective on the use of low-dose OM for AGA, see a review written for the JAAD which includes clinical trial data and mentions the warnings associated with the drug. Several years from now, it may be possible to evaluate longer term use of low-dose OM for AGA and compare its safety to the relatively short-term studies linked above, which were found to be generally favorable. Low-dose oral minoxidil should always be used under doctor’s supervision. from Follicle Thought
Rosemary Oil and Hair Growth is all the talk these days. Last August I included an article in my newsletter under 3 Hair Trends That Will Be Everywhere This Summer about Rosemary Oil for Hair Growth. Below is the article "Should I Use Rosemary Oil for Hair Growth?" from Healthline.com Should I Use Rosemary Oil for Hair Growth?
Topically applied rosemary oil may help support hair growth and prevent hair loss. But applying too much can cause side effects. Rosemary essential oil and hair Rosemary is a culinary and healing herb. This woody perennial is native to the Mediterranean region, where it’s been used as food and medicine for centuries. Much like oregano, peppermint, and cinnamon, rosemary is frequently found in essential oil form. Essential oils are highly concentrated and distilled extracts of volatile plant compounds. These are used for cooking, cleaning, beauty, health, and other purposes. Rosemary essential oil is a common variety you can purchase and use as a home remedy. The oil’s health uses range from antioxidant benefits and anti-inflammation to memory enhancement and more. In recent years, there have been claims that the oil may be great for hair growth. Some say it could even prevent hair loss, pointing to Mediterranean cultures’ use of rosemary in hair rinses to promote hair growth for hundreds of years as supporting evidence. Can rosemary oil treat hair loss? The idea that rosemary oil encourages hair growth may come from the rosemary’s basic health benefits. The plant in essential oil form is said to:
Like peppermint essential oil (also used to promote hair growth), rosemary essential oil strengthens circulation. As a result, it could prevent hair follicles from being starved of blood supply, dying off, and leading to hair loss. Beyond stimulating hair growth, rosemary essential oil is used to prevent premature graying and dandruff. It may also help dry or itchy scalp. Do studies support the claims? According to some scientific evidence, rosemary may benefit nerve tissue. Carnosic acid, an active ingredient in the plant, healed tissue and nerve damage in one study. This ability to heal nerve endings may rejuvenate nerves in the scalp too, in turn possibly restoring hair growth. More revealing recent studies show that rosemary directly helps protect against hair loss. One 2015 trialTrusted Source pitted the essential oil against minoxidil, commercially known as Rogaine. Both were used on human subjects with androgenetic alopecia (male or female pattern baldness). Results showed that rosemary essential oil was just as effective a minoxidil. During the process, it helped the side effect of itchy scalp more successfully than minoxidil. Another studyTrusted Source of rosemary leaf extract (different from the essential oil) showed it stimulated hair growth. This occurred when hair loss was triggered by testosterone (as in pattern baldness). This study was performed on mice, however. Two separate clinical reviews — one from 2010Trusted Source and one from 2011 — also acknowledge rosemary’s hair growth potential. The former cites a study with successful hair regrowth in people with alopecia who used essential oils. One of these essential oils was rosemary. In the latter review, rosemary essential oil was described as a hair loss restorative. This was due to its circulation-improving effects. How should I use rosemary oil for hair loss? Here are a few ways to try using rosemary essential oil as a hair restorative and thickener. Try any of these treatments one to two times per week to start out. Use them more often when desired or you’ve become comfortable using them. 1. Massage it directly into your scalpAfter mixing about 5 drops of rosemary essential oil with a teaspoon of carrier oil (like jojoba oil or coconut oil), massage evenly into your scalp after bath or shower. Rinsing out the oil afterward is optional — though if you do rinse, let the oil sit on your scalp for at least 5 to 10 minutes beforehand. 2. Mix it into your shampooThis can also apply to conditioners, lotions, or creams. Play it safe and don’t add too much. Keep to about five drops per ounce of product. Afterward, use the product like usual. You can also add 2 to 3 drops directly to any hair product when you apply a dollop of it on your palm before use. 3. Add it to your own homemade shampooThere are many recipes online for a shampoo base. You can also add essential oils for your preferred health and beauty benefits. These may incorporate a mixture of baking soda, coconut oil, essential oil, and possibly other oils. Try this one at Tiny Apothecary. What should I know before using rosemary oil? Avoid getting essential oil in your eyes. If contact occurs, quickly rinse your eyes with cold water. Likewise, be careful not to apply too much to your scalp. Rosemary essential oil has been known to irritate the skin. It may cause discomfort, but no health dangers. To avoid skin irritation, dilute the oil with a carrier oil or other product before applying it. Not enough is known about the safety of using rosemary essential oils while pregnant or breastfeeding. Though using the essential oil for hair loss is only done topically, be cautious — its effects in this regard are still unknown. The bottom line Rosemary has been used by many to promote hair growth successfully. Using rosemary essential oil could very well do the same for you. Science and personal experience together both strongly suggest the essential oil does protect against hair loss, particularly that related to male or female pattern baldness. It may even be effective for alopecia. Rosemary essential oil is a simple remedy that you can use at home, and it may even be competitive with commercial products. What’s more, it’s quite safe when used correctly and yields very few side effects. |
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